Mapping concentrated solar power site suitability in Algeria

The investment in solar thermal power technologies has become increasingly attractive, despite their still perceived high costs. Algeria presented an ambitious plan for increasing the participation of renewable energy sources (RES) in the power system, with significant investments foreseen for solar power technologies. To achieve this objective, it is necessary to identify optimal sites for the implementation of these plants, as well as others where implementation is highly inadvisable from the economic, social, or environmental points of view. The main goal of this study is to present and apply a methodology to identify adequate locations for the installation of solar power plants in Algeria. The study addressed the particular case of concentrated solar power (CSP) and proposed a hybrid approach combining multi criteria decision making and Geographic Information System. The approach allowed mapping and visualizing unfeasible areas and ranking the feasible sites. The results showed that more than 51% of the territory of the country is unfeasible for the implementation of CSP, mainly due to criteria related to topographic aspects, water availability, and distance to the grid. The results demonstrated that relying only on Direct Normal Irradiation (DNI) values may result in a reductionist vision for energy planning and thus other criteria can play a fundamental role in the decision process. The model allowed also to identify the best regions for CSP investment and opens routes for more detailed studies for the exact site selection.The authors would like to thank all open source data providers and ESRI Maps for provide the background maps. Also authors thank J. R. Oakleaf et al. for make available spatial data linked to global potential for renewable energy. The authors are also thankful to experts of the research center CDER and the engineering experts who participated in the AHP for their assistance

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Géographie de l'énergie solaire en Andalousie (Sud de l'Espagne) : Nouvelles données et possibilités d'analyse

This work provides spatial information of photovoltaic and solar thermal power plants installed in Andalusia, as well as alphanumeric information on the type of plant and the installed power. To this end, the polygons corresponding to the solar power plants installed in the region are digitised at a detailed scale and from the latest available aerial orthophotography. In addition, an exploratory analysis is carried out with the information generated, calculating indicators that have not been developed to date in the Autonomous Community. The main results obtained include the higher land consumption per installed power of solar thermal power plants, the identification of municipalities where the presence of these facilities already occupies the 15% of their territory, and the difference in land consumption patterns for each type of plant. Access and reuse of the information is guaranteed by means of a web map with Web Feature Services (WFS), which will allow not only geovisualisation, but also data downloading. The availability of this information makes it possible to go beyond the analyses carried out to date, which were based on a specific layer of the Andalusian Energy Agency distributed by the Institute of Statistics and Cartography of Andalusia.El presente trabajo pone a disposición la información espacial relativa a las centrales fotovoltaicas y termosolares instaladas en Andalucía, además de información alfanumérica sobre el tipo de central y la potencia instalada. Para ello se digitalizan a escala detallada y a partir de la última ortofotografía aérea disponible los polígonos correspondientes a centrales solares instaladas en la región. Además, se realiza un análisis exploratorio con la información generada, calculando indicadores no desarrollados hasta el momento en la Comunidad Autónoma. Entre los principales resultados obtenidos destacan el mayor consumo de suelo por potencia instalada de las centrales termosolares, la identificación de municipios donde la presencia de estas instalaciones ocupan ya el 15% de su territorio, o la diferencia en los patrones de consumo de suelo de cada tipo de central. El acceso y la reutilización de la información se garantizan mediante un mapa web con servicios Web Feature Services (WFS), que permitirá no sólo la geovisualización, sino la descarga de datos. La disponibilidad de esta información permite superar los análisis realizados hasta el momento, basados en una capa puntual procedente de la Agencia Andaluza de la Energía distribuida por el Instituto de Estadística y Cartografía de Andalucía

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Microbiomes are vast communities of microbes and viruses that populate all natural ecosystems. Viruses have been considered the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared to other environments. Here we investigate the origin, evolution, and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboratory, we obtained DNA sequences of crAssphage from over one-third of the world's countries, and showed that its phylogeography is locally clustered within countries, cities, and individuals. We also found colinear crAssphage-like genomes in both Old-World and New-World primates, challenging genomic mosaicism and suggesting that the association of crAssphage with primates may be millions of years old. We conclude that crAssphage is a benign globetrotter virus that may have co-evolved with the human lineage and an integral part of the normal human gut virome

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Microbiomes are vast communities of microorganisms and viruses that populate all natural ecosystems. Viruses have been considered to be the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared with that of other environments. Here, we investigate the origin, evolution and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboration, we obtained DNA sequences of crAssphage from more than one-third of the world's countries and showed that the phylogeography of crAssphage is locally clustered within countries, cities and individuals. We also found fully colinear crAssphage-like genomes in both Old-World and New-World primates, suggesting that the association of crAssphage with primates may be millions of years old. Finally, by exploiting a large cohort of more than 1,000 individuals, we tested whether crAssphage is associated with bacterial taxonomic groups of the gut microbiome, diverse human health parameters and a wide range of dietary factors. We identified strong correlations with different clades of bacteria that are related to Bacteroidetes and weak associations with several diet categories, but no significant association with health or disease. We conclude that crAssphage is a benign cosmopolitan virus that may have coevolved with the human lineage and is an integral part of the normal human gut virome.status: publishe

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present